发明名称 |
Process for the purification of glucosaminoglucans |
摘要 |
A process for the removal of components having low or no anticoagulant activity from a glucosaminoglucan is described which comprises subjecting said glucosaminoglucan in the form of a salt in an aqueous solution to flow across a membrane suitable for ultrafiltration, hyperfiltration (inverse osmosis) or dialysis with partial passage through said membrane, whereby fractions of low activity go through the membrane and fractions of higher activity do not go through the membrane and are concentrated. The membrane suitable for ultrafiltration may have a nominal molecular cut-off between 1000 and 15,000. The membrane suitable for dialysis may have a nominal molecular cut-off at less than 30,000. The glucosaminoglucan may be heparin in the form of the sodium or calcuium salt.
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申请公布号 |
US4507205(A) |
申请公布日期 |
1985.03.26 |
申请号 |
US19810237880 |
申请日期 |
1981.02.25 |
申请人 |
ITALFARMACO S.P.A. |
发明人 |
CREMONESI, PIETRO;SPORTOLETTI, GIANCARLO |
分类号 |
C08B37/10;(IPC1-7):B01D13/00 |
主分类号 |
C08B37/10 |
代理机构 |
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