SPERGUALIN-BESLAEGTEDE FORBINDELSER MED EN PHENYLENGRUPPE, FREMGANGSMAADE TIL FREMSTILLING DERAF SAMT DERES ANVENDELSE SOM LAEGEMIDLER

摘要

The present invention reales to novel Spergualin related compounds, and a process for producing the same. More particularly, the invention reales to Spergualin related compounds of the formula: …… wherein R1 is a lower alkylene group which may be substituted by a hydroxymethyl group; X is a hydrogen atom or a halogen alom; m and n are each 0 or an integer of 1 to 5, and salts thereof, as well as a process for producing the compounds of formula (I) and salts thereof by removing the protecting groups from a protected Spergualin related compounds of the formula: …… wherein R1 is a straight chain or branched lower alkylene group which may be substituted by a hydroxymethyl group, the hydroxyl group of which may be protected; R2 is an amino protecting group; R3 is a protected amino group; X, m and n are as defined above. …The compounds of the formula I have anti-tumor activity and can therefore be used as medicaments.