发明名称 |
DIPEPTIDET PYRGLU-HIS(2,4-DINITROPHENYL)-OH OG FREMGANGSMAADE TIL FREMSTILLING AF LH-RH OG LH-RH-ANALOGE PEPTIDER UNDER ANVENDELSE AF DETTE DIPEPTID |
摘要 |
<p>What is disclosed is a method for the manufacture of LH-RH and LH-RH analogs, which comprises reacting Glu-His(DnP)-OH with the corresponding peptide having a free amino group and protected carboxy groups in a solvent as used in peptide chemistry and with the addition of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine (HOObt) and a carbodiimide and then splitting off the Dnp-(2,4-dinitrophenyl) group. The new method greatly reduces the degree of histidine racemization. The invention also provides a new dipeptide, i.e. Glu-His(Dnp)-OH.</p> |
申请公布号 |
DK148085(B) |
申请公布日期 |
1985.02.25 |
申请号 |
DK19800000611 |
申请日期 |
1980.02.13 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
WOLFGANG KOENIG;VOLKER TEETZ;GEORG JAEGER;ROLF GEIGER |
分类号 |
C07K7/06;A61K38/00;C07C231/00;C07K1/06;C07K5/06;C07K5/078;C07K7/23;C07K14/575;(IPC1-7):C07K5/06;C07K7/20 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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