SUBSTITUTED DEOXYADENOSINE DERIVATIVES

摘要

SUBSTITUTED DEOXYADENOSINE DERIVATIVES Novel compounds of the following general formula I are useful pharmacological agents: Formula I wherein: Ado represents 5'-deoxyadenosin-5'-yl; R1 represents methyl, ethyl or, preferably hydrogen; R2 represents C1-C8 alkylene; R4 represents C1-C8 alkylene; R5 represents hydrogen, C1-C6 alkyl or -R6 NHR7; R6 represents C1-C4 alkylene; and R7 represents hydrogen or C1-C6 alkyl; and pharmaceutically acceptable acid addition salts thereof. These compounds are useful for treating those disorders associated with elevated levels of spermidine and/or spermine or pathogenic protazoa.