Hypotriglyceridemically active polysaccharides.

摘要

A hypotriglyceridemically active polysaccharide having the following characteristics: (a) Specific rotatory power:<MathDetails id="matha01"><MathText><![CDATA[ <img id="ia01" file="imga0001.tif" wi="29" he="4" img-content="math" img-format="tif" inline="no" /> ]]></MathText></MathDetails>(1.8 w/v% solution) (b) Molecular weight by gel filtration:<MathDetails id="matha02"><MathText><![CDATA[ <img id="ia02" file="imga0002.tif" wi="28" he="3" img-content="math" img-format="tif" inline="no" /> ]]></MathText></MathDetails><UnorderedLists id="ula01" listStyle="none"><ListItem>(c) Sugar composition (weight percent by gas chromatography)<Image id="ia03" he="10" wi="35" file="IMGA0003.TIF" imgContent="table" imgFormat="TIFF" inline="no" /></ListItem><ListItem>(d) Acid-base characteristic: neutral polysaccharides</ListItem><ListItem>(e) Physiological characteristics: capable of reducing the blood triglyeride in mammals.</ListItem></UnorderedLists>

This hypotriglyceridemically active polysaccharide can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypotriglyceridemically active polysaccharide from the cultured cells of the microorganism and/or the supernatant of the culture broth. The present hypotriglyceridemically active polysaccharide can be used as an active ingredient of a hypotriglyceridemic or antithero- sclerotic pharmaceutical composition together with pharmaceutically acceptable carrier therefor to form a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition, which is suitable for oral administration to mammals.