ISOLATION AND/OR PRESERVATION OF DENDRITIC CELLS FOR PROSTATE CANCER IMMUNOTHERAPY
摘要
Methods and compositions for use of human dendritic cells to activate T cells for immunotherapeutic responses against primary and metastatic prostate cancer are disclosed. In one embodiment, human dendritic cells, after exposure to a prostate cancer antigen or specific antigenic peptide, are administered to a prostate cancer patient to activate the relevant T cell responses in vivo. In an alternate embodiment, human dendritic cells are exposed to a prostate cancer antigen or specific antigenic peptide in vitro and incubated or cultured with primed or unprimed T cells to activate the relevant T cell responses in vitro. The activated T cells are then administered to a prostate cancer patient. Methods and compositions for human dendritic cells with extended life span and cryopreserved dendritic cells are disclosed.
申请公布号
WO9704802(A1)
申请公布日期
1997.02.13
申请号
WO1996US12389
申请日期
1996.07.29
申请人
PACIFIC NORTHWEST CANCER FOUNDATION;MURPHY, GERALD, P.;BOYNTON, ALTON, L.;TJOA, BENJAMIN, A.
发明人
MURPHY, GERALD, P.;BOYNTON, ALTON, L.;TJOA, BENJAMIN, A.