| 摘要 |
<p>Compounds are described of the formulae (1a) and 1b) <IMAGE> in which: R1 is -H, C1-6 alkyl or C7-10 aralkyl, W is C1-7 alkylene X is cis or trans -CH=CH-, Y is a saturated heterocyclic amino group having 5-8 ring members, R2 is (i) substituted or unsubstituted phenylalkyl, thienylalkyl or naphthylalkyl or (ii) cinnamyl, and Z is -CH2OH, -CHO or -CONHR4 where R4 is -H or methyl, and their salts and solvates. These compounds inhibit blood platelet aggregation, bronchoconstriction and vasoconstriction, and may be formulated for use as antithrombotic and antiasthmatic agents.</p> |
