发明名称 |
VERFAHREN ZUR HERSTELLUNG VON HALBSYNTHETISCHEN CEPHALOSPORINEN |
摘要 |
<p>Semisynthetic cephalosporins of the formula: <IMAGE> wherein R is a hydrogen atom or a Cl-(CH2)3-CO-, Ph-CH2-O-CO- or Cl3C-CH2-O-CO- group or other amino protecting group and R' is a hydrogen atom or a Cl3-C-CH2- or CH(C6H5)2- group or other carboxy protecting group, are made by reacting an N-protected alpha-phenylglycine of the formula: <IMAGE> with an N-chlorocarbonyl-sec.amide or lactam of the formula: <IMAGE> wherein X is a bis(mono-C1-C6-alkyl) group, a C1-C6-alkyl diradical, a C1-C4- alkyl diradical containing a hetero-atom selected from N, O and S or a <IMAGE> group, wherein Y is a C1-C6 group or a C0-C4 group containing a heteroatom selected from N, O and S and n is an integer from 0 to 3, and subjecting the resultant mixed anhydride to selective aminolysis with an ester of 7- aminodeacetoxy-cephalosporanic acid. The final products are antibacterial agents or intermediates for their synthesis.</p> |
申请公布号 |
ATA275082(A) |
申请公布日期 |
1984.12.15 |
申请号 |
AT19820002750 |
申请日期 |
1982.07.15 |
申请人 |
SOUR PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA, N.SOL.O. |
发明人 |
KOVACEVIC MICE DR.;HERAK JURAJ DR.;GASPERT BRANIMIR DR. |
分类号 |
A61K31/545;C07D501/00;C07D501/02;C07D501/04;C07D501/06;C07D501/22;(IPC1-7):C07D501/02 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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