| 摘要 |
PURPOSE:To obtain the titled substance economically with causing almost no side reactions, by reacting a thiol with chlorodifluoromethane in the presence of an equimolar or a little excess amount of a basic substance in a strongly polar aprotic solvent. CONSTITUTION:A thiol shown by the formula I (R is aromatic, or heterocyclic residue) is reacted with chlorodifluoromethane in the presence of 1-4 times as much a basic catalyst (e.g., alkali metal hydroxide, carbonate, bicarbonate) as the thiol by the use of a strongly polar aprotic solvent at 50-120 deg.C to give a compound shown by the formula II. The solvent has >=dielectric constant, >=2.5D dipole moment, and 40-47 Etau(30) value, one of solvent polarity parameter, and DMSO, DMF, etc. may be cited as the solvent. EFFECT:A solvent, and chlorodifluoromethane can be efficiently used, and, since the amount of a basic substance used is small, the load of waste water treatment can be extremely reduced.
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