| 摘要 |
<p>The invention concerns compounds with thromboxane synthetase inhibitor properties of the formula I <CHEM> wherein R1 represents hydrogen or lower alkyl; Im represents 1-imidazolyl unsubstituted or substituted by lower alkyl, carboxy, lower alkoxycarbonyl or carbamoyl; R2 and R3 independently represent hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy, lower alkoxy, lower alkyl (thio, sulfinyl or sulfonyl), or R2 and R3 together when attached to adjacent carbons represent lower alkylenedioxy; A represents alkylene of 1 to 12 carbon atoms, alkenylene of 2 to 12 carbon atoms, alkynylene of 2 to 12 carbon atoms, lower alkylenephenylene lower alkylene, lower alkylenephenylene, phenylene-lower alkylene, phenylene, a direct bond, lower alkylene-(thio or oxy) lower alkylene (thio or oxy)-phenylene, lower alkylene-(thio or oxy)-phenylene, phenylene (thio or oxy) lower alkylene or phenylene lower alkenylene; B represents carboxy, lower alkoxycarbonyl, carbamoyl, mono- or di-lower alkylcarbamoyl, cyano, hydroxymethyl, hydroxycarbamoyl, 5-tetrazolyl or formyl; the N-oxides thereof; and salts thereof. They are prepared, for example, by condensing a compound corresponding to the formula I, in which the nitrogen atom carries only a hydrogen atom, with a reactive functional derivative of a compound of the formula HOCH2-A-B.</p> |
