| 摘要 |
PURPOSE:The titled composition having improved absorption of a drug from the rectum, obtained by blending a base for pharmaceutical preparation of rectum administration with a specific fatty acid and a nonionic surface active agent. CONSTITUTION:A base for pharmaceutical preparation of rectum administration (e.g., cacao butter, polyethylene glycol, etc.) is blended with (A) at least one selected from 8-10C fatty acid and its salt, and (B) at last one selected from nonionic surface active agents. Capric acid and caprylic acid are preferable as the component A. Polyoxyethylene alkyl ether, glycerine fatty acid ester, etc. are used as the component B. Administration of the titled composition together with a drug can raise rectum absorption of the drug. It further enables rectum administration of a drug which is slightly absorbed in the rectum and has not been admistered as medicine heretofore.
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