PROCESS FOR PREPARING ANTIBIOTIC DERIVATIVES OF NEPLANOCINE

摘要

NEW MATERIAL:Neplanocin D of formula I (R1 is OH, SH, SCH3, or Cl; R2 is H or protecting group), and its derivative. EXAMPLE:Neplanocin D of formula II. USE:An intermediate for the synthesis of anti-cancer drugs, capable of synthesizing anti-cancer drug Neplanocin A of formula III via the derivative. PROCESS:Ampullariella sp.-A11079 strain (FERM-P No.4494) is incubated in a liquid medium aerobically for 2-4 days, and Neplanocin D is adsorbed on active carbon from the culture filtrate, and eluted by hydrous methanol. The eluate is then separated by and adsorbent and ion exchange resin, and purified by recrystallization to give Neplanocin D. A protecting group and mercapt group are introduced, and the reaction product is alkylated to afford a novel derivative.