| 摘要 |
<p>PURPOSE:To obtain the titled compound having antibacterial activity against Gram-positive and Gram-negative bacteria, with shortened steps, by reacting a specific cephalosporanic acid compound with a specific carboxylic acid (or its reactive derivative), and hydrolyzing the reaction product. CONSTITUTION:The objective compound of formula V can be prepared by reacting the compound of formula I [R<1> is group of formula II (R<3>-R<5> are H or oranic residue) or formula III (R<6> and R<7> are H or organic residue); R<2> is H, carboxyl-protecting group or salt-forming cation; R<8> is H, cyano, azido, or organic group bonded through O or S] with the carboxylic acid of formula IV [R is amino acid residue; A is H, (substituted) alkyl, cycloalkyl, aryl, etc.; R<9> and R<10> are H, (substituted) alkyl or aryl; Y is O or S] or its reactive derivative at the carboxyl group, preferably in an inert solvent at -20-+20 deg.C, and then hydrolyzing the reaction product.</p> |
