| 摘要 |
The -adrenoceptor antagonistic benzoquinolizines [I; R7 = lower alkyl, (un)substituted Ph, (un)substituted naphthyl; R8 = Me or Et were prepd. from the reaction of R7SO2OH and 2β-ethylaminoor methylamino-1,3,4,6,7,11b α-hexahydro 2H-benzo[A quinolizine. Thus, 2β-amino-1,3,4,6,7,11b α-hexahydro-2H-benzo≮α≉quinolizine was formylated with HCO2H, reduced, and then treated with MeSO2Cl to give I[R8 = R7 = Me , whose presynaptic- -adrenoceptor antagonist PA2 = was 7.7.
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