| 摘要 |
NEW MATERIAL:The compound of formula I [R1 is alkyl; R2 is H or lower alkyl; X is -C(CO)-O- or -O-C(O)-]. EXAMPLE:Butoxycarbonylmethyl prostaglandin E1 ester. USE:Hypotensor and antithrombotic agent. It can be extremely easily converted to a fat emulsion, and has high ED50 value. PREPARATION:The compound of formula I can be prepared by reacting prostaglandin E1 with the ester compound of formula II (X is halogen, OH or diazo) preferably in the presence of a phase-transfer catalyst [e.g. (CH3)4NBr, (CH3H7)4Nbr, etc.]. The compound has hypotensive and blood platelet coagulation suppressng effect, etc. The conversion of the compound to a fat emulsion is preferably carried out by conventional means using a vegetable oil such as soybean oil, cottonseed oil, etc. Dose: usually 1-100mug for an adult by intravenous injection when used as an antithrombotic agent in the form of a fat emulsion.
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