PROCEDIMIENTO PARA PREPARAR UNA FORMA DE 4-HIDROXI-2-METIL-N-(5-METIL-3-ISOXAZOLIL)-2H-1, 2-BENZOTIAZIN-3-CARBOXAMIDA 1, 1-DIOXIDO FINAMENTE CRISTALINA, BIEN REABSORBIBLE

摘要

A new process for the preparation of microcrystalline isoxicam having a particle size of about 1-30 mu m which comprises dissolving isoxicam in a mixture consisting of a solvent miscible with water and of an aqueous base where the resulting basic solution is neutralized with dilute acid to a pH of 4-6 with vigorous agitation precipitating the microcrystalline product is herein described.