ESTRADIOL CONTAINING TRANSDERMAL DRUG DELIVERY SYSTEMS AND COMPOSITIONS

摘要

Transdermal drug delivery systems and compositions containing estradiol. The systems and compositions can include levulinic acid in an amount to enhance transdermal permeation of estradiol and a pharmaceutically acceptable carrier. The systems and compositions can optionally include a solubilizing agent and additional permeation enhancers. Pharmaceutically acceptable carriers can include adhesives, particularly acrylate copolymers, gels, creams, ointments, solutions, suspensions, and pastes.