NEW OCTAHYDROBENZO (f) QUINOLINE DERIVATIVES

摘要

Compounds of the formula (I), wherein C<1> and N<4> are in trans configuration to each other, Y is OH, R<1>COO, R<2>R<3>NCOO- or R<4>O whereby R<1> is an aliphatic hydrocarbon residue having 1-17 carbon atoms, a phenyl, 2,6-dimethylphenyl or 3- or 4-hydroxyphenyl group or a 3- or 4-alkanoyloxyphenyl group with the formula (II), wherein R<5> is an alkyl group having 1-6 carbon atoms, or R<1> is a group (III) wherein R<6> is hydrogen, an alkyl group having 1 to 5 carbon atoms or a phenyl group, R<7> is hydrogen, and alkyl group having 1 to 5 carbon atoms or an acyl group and R<8> is hydrogen or an alkyl group having 1 to 5 carbon atoms, R<2> is hydrogen, an alkyl group having 1-5 carbon atoms, a phenethyl, benzyl or phenyl group which may be mono- or disubstituted in the aromatic part with a methyl, methoxy, hydroxy, nitro or cyano group or a halogen, R<3> is H, an alkyl group having 1 to 5 carbon atoms of a phenyl group or R<2> and R<3> together with the nitrogen atom form a 5, 6 or 7 membered ring that may contain 1 to 3 double bonds and/or 1 or 2 further heteroatoms selected from N, O and S, and R<4> is an allyl or benzyl group and R is hydrogen or the group (IV) wherein n is 3 or 4 and R<9> is hydrogen, an alkanoyl group having 2-6 carbon atoms or benzoyl as bases and pharmaceutically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for treatment of disorders in the central nervous system.