| 发明名称 | Combination adjuvant formulation | ||
| 摘要 | Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen. | ||
| 申请公布号 | US9408908(B2) | 申请公布日期 | 2016.08.09 |
| 申请号 | US201313768694 | 申请日期 | 2013.02.15 |
| 申请人 | University of Saskatchewan ;The University of British Columbia ;Dalhousie University ;International Vaccine Institute | 发明人 | van den Hurk Sylvia;Gerdts Volker;Potter Andrew;Babiuk Lorne;Hancock Robert;Halperin Scott;Kovacs-Nolan Jennifer;Mutwiri George;Lee Song;Kweon Mi-Na;Kindrachuk Jason;Elliott Melissa |
| 分类号 | A61K39/39;A61K39/12;A61K47/30;A61K45/06;A61K39/155;C07K7/08;A61K39/02;A61K39/00 | 主分类号 | A61K39/39 |
| 代理机构 | Robins Law Group | 代理人 | Robins Roberta L.;Robins Law Group |
| 主权项 | 1. An adjuvant composition comprising a host defense peptide, an immunostimulatory sequence, a viral antigen and a polyanionic polymer, wherein the polyanionic polymer is poly[di(sodium carboxylatophenoxy)phosphazene] (PCPP), poly(di-4-oxyphenylproprionate)phosphazene (PCEP), or a PCPP polymer comprising 90% PCPP copolymer with 10% hydroxyl groups (90:10 PCPP), wherein said adjuvant composition is capable of enhancing an immune response in a subject to the viral antigen as compared to the immune response elicited by an equivalent amount of the viral antigen when delivered to the subject without the adjuvant composition. | ||
| 地址 | Saskatoon CA | ||