发明名称 1-Phenethyl-alpha-phenyl-piperidine-3-propanenitriles and their pharmaceutical uses
摘要 Compounds of the formula: <IMAGE> wherein R1, R2, R3, R4 and R5 each represent a hydrogen atom, a halogen atom, a (C1-4)alkoxy radical, a (C1-4)alkylthio radical, a halogeno(C1-4)alkyl radical, a (C1-4)alkyl radical or a cycloalkyl-alkoxy-alkoxy radical or two of the adjacent R symbols together form a methylenedioxy or ethylenedioxy radical, R6 represents a hydrogen atom, a (C1-4)alkyl radical, a (C3-6)cycloalkyl radical or a (C3-6)cycloalkyl-(C1-4)alkyl radical, and R7, R8 and R9 each represent a hydrogen atom or a methoxy radical, are new compounds possessing pharmacological properties; they are useful as calcium antagonists and as antihypertensives.
申请公布号 US4481207(A) 申请公布日期 1984.11.06
申请号 US19830523349 申请日期 1983.08.15
申请人 SYNTHELABO 发明人 MANOURY, PHILIPPE;BINET, JEAN;DEFOSSE, GERARD
分类号 A61K31/443;A61K31/445;A61K31/451;A61P3/00;A61P3/14;A61P9/08;A61P9/12;C07C67/00;C07C253/00;C07C255/37;C07D211/18;C07D211/22;C07D211/30;C07D211/34;C07D211/60;C07D317/00;C07D317/64;C07D319/00;C07D405/06;(IPC1-7):A61K31/44 主分类号 A61K31/443
代理机构 代理人
主权项
地址