发明名称 |
Vitamin D metabolism inhibitor |
摘要 |
This invention provides a novel vitamin D derivative, namely a 24-oxime derivative of vitamin D3, and a process for its preparation. The compound of this invention is an effective inhibitor of vitamin D-25-hydroxylation and markedly suppresses the formation of the physiologically active vitamin D metabolites. The compound would thus find use as an effective antagonist of vitamin D activation, and for treating hypercalcemic conditions resulting from metabolic, bone, or neoplastic diseases, or from vitamin D intoxication.
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申请公布号 |
US4481198(A) |
申请公布日期 |
1984.11.06 |
申请号 |
US19840579620 |
申请日期 |
1984.02.13 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, HECTOR F.;SCHNOES, HEINRICH K.;CHU, JOHN Y.;KABAKOFF, BRUCE D. |
分类号 |
C07C401/00;C07J9/00;(IPC1-7):C07J9/00 |
主分类号 |
C07C401/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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