| 摘要 |
<p>NEW MATERIAL:A compound shown by the formula I [R1-R3 are H, or substituent group known in imidazole skeleton; R4 is H, or methoxy; R5 is H, or protecting group which can be eliminated in organisms; X is (protected)amino, or (protected) carboxyl-containing substituent group at 3-position] and its salt. EXAMPLE:7-beta( Imidazol-2-yl-amino )-3-[4-( 2'-amino-2'-carboxy ) ethylimidazol-2-yl- thiomethyl]-3-cephem-4-carboxylic acid. USE:An antibacterial agent. PREPARATION:For example, a compound shown by the formula II is reacted with a compound shown by the formula H-Z [Z is shown by the formula III, or formula IV (B is 5-6-membered heterocyclic ring containing 1-4 hetero atoms of N, O, and S; B' is 5-6-membered heterocyclic ring containing 1-3 hetero atoms of N, O, and S; n is 0-4; R6 and R7 are protective group, or H)] preferably at 5-7pH at 10-80 deg.C for 1-10hr.</p> |
