| 摘要 |
Compounds of the structure <IMAGE> wherein: P and Q are independently hydrogen, halo, CF3, OR1, SR1, sulfamoyl, alkyl and NR1R2; R1, and R2 are independently hydrogen, alkyl, aminoalky, aryl, aralkyl, heteroaryl or cycloalkyl; Y is OH, OR1, NH2, or, N(R1R2); and M is alkyl, cycloalkyl, aryl, aminoalkyl, aralkyl, heteroaryl or heterocyclic wherein: the alkyl groups and the alkyl moieties of aminoalkyl, alkoxy and thioalkyl contain from 1 to 6 carbon atoms; the cycloalkyl group contains from 3 to 8 carbon atoms; the aryl group contains from 6 to 10 carbon atoms; the aralkyl group contains from 7 to 16 carbon atoms; and the hetero group is selected from pyrrolidyl, piperidinyl, morpholinyl, pyridyl, quinolinyl, furyl, furfuryl and thienyl; and where Y is a hydroxy, their pharmaceutically acceptable, non-toxic alkali, alkaline earth and amine salts, have angiotensin converting enzyme inhibitory activity.
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