| 摘要 |
<p>Nitroarylacetic acid esters are prepared by reacting a nitroaromatic compound with an alpha,alpha-disubstituted acetic acid ester in a substantially anhydrous aprotic solvent and in the presence of a base so that the ester undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. The nitroarylacetic acid esters formed by the process can be readily converted into derivatives, such as pharmaceuticals.</p> |
