Renin inhibitors

摘要

A compound of the formula Z-His-Pro-Phe-His-X-X-Val-Tyr-(D-)-Y wherein the Xs are the same or different and selected from the group consisting of an aromatic, a chlorinated aromatic, an aliphatic and a chlorinated aliphatic amino acid residue; Y is a positively or negatively charged amino acid residue; and Z is a proline or a polyprolyl residue having up to 5 prolyl residues, is useful for decreasing renin-related high blood pressure.