发明名称 PROCESS FOR THE PREPARATION OF 1-ARYLOXY-3-ALKYLAMINO-2-PROPANOLS
摘要 The title compds. I≮R1 = C1-20, n-, or branched alkyl; R2 = H, halo, C1-4, n- or branched alkyl, alkoxy, (CH2)n n = 3-5;R3 = C3-10 n- or branched alkyl! were prepd. Thus, 10g 1-(2-cyano- 4-hexanoilaminophenoxy)-2,3-epoxypropanol was dissolved in 1000 ml EtOH, and 8.3g isopropylamine was added. The mixt. was refluxed and recrystalized with acetonitryl for 1 hr. to give 3.8g I. I can be used in the treatment or prevention of coronary heart disease and angina.
申请公布号 KR840001840(B1) 申请公布日期 1984.10.22
申请号 KR19810001406 申请日期 1981.04.23
申请人 C.H.BOEHRINGER SOHN 发明人 KOEPPE HERBERT;STAEHLE HELMUT;KUMMER WERNER;MUACEVIC GOJKO
分类号 C07C253/30;A61K;A61K31/045;A61K31/13;A61K31/135;A61K31/16;A61K31/165;A61K31/275;A61P9/08;A61P9/12;C07C;C07C33/00;C07C67/00;C07C231/00;C07C253/00;C07C255/59;C07C255/60;C07D239/42;C07D239/47;C07D239/52;C07D239/70;C07D251/12;C07D251/46;C07D491/048;C07D491/052;(IPC1-7):C07C121/80 主分类号 C07C253/30
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