| 摘要 |
PURPOSE:To provide an acrylic adhesive plaster having improved decomposition stability of the drug component in the plaster, and obtained by compounding gamma-oryzanol to an adhesive pharmaceutical plaster composed of an acrylic adhesive substance. CONSTITUTION:An adhesive pharmaceutical plaster composed of an acrylic adhesive plaster is compounded with about 0.005-3wt%, preferably about 0.05- 1wt%, based on the whole plaster, of gamma-oryzanol. The decomposition of a drug having phenolic OH-group and/or amino group and highly unstable in the plaster, e.g. salicylic acid derivative useful as an anti-inflammatory and analgesic agent, vitamin E, capsaicin, an ethanolamine antihistaminic agent such as diphenhydramine, etc. can be suppressed, and the drug activity can be maintained stably for a long period. A gamma-oryzanol-containing substance, such as organic solvent extract of a gamma-oryzanol-containing vegetable, etc. may be used in place of pure gamma-oryzanol.
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