| 摘要 |
Cephems I [R1=(protected) amino; R2=alkyl, (protected) aminoalky1, hydroxyalkyl, alkythioakyl, carboxyalkyl, alkenyl, alkynyl, cycloalkyl, etx. ; R3=(protected)aminoalkyl, hydroxyalkyl, etc.; R4=(protected) carboxy; when R2=lower alkyl, R3=hydrocyalkyl, etx were prepd. Thus syn-7-[2-(2-formamidothiazole-4-yl)-2-methoxyiminoacetamido -3-[1-(2-hydroxythyl-lh-tetrazol-5-yl thiomethyl -3-cephem-4-carboxylic acid was reacted with 0.73g conc. Hcl and 14.0g methanol for 3 hrs. at room temp. to give 7-[2-aminothiazole-4-yl -2-methoxyiminoacetamido -3-[1-(2-hydroxyethyl-l-tetrazole-5yl thiomethyl -3-cephem-4-carboxylic acid.
|
