| 摘要 |
<p>Trisubstituted oxazolidinones of the formula <IMAGE> where R1 is an aryl or heteroaryl radical, R2 and R3 independently of one another are hydrogen or lower alkyl or, together, are lower alkylene, and alk is lower alkylene, whose valences are derived from carbon atoms which are adjacent or in the 1,3-position relative to each other, with the proviso that, in compounds with (-)-trans-arrangement of the hydrogen atoms in the 4- and 5-position of the oxazolidine ring, R1 is other than unsubstituted phenyl when R2 and R3 are hydrogen and alk is 1,3-propylene, are proposed as antidepressive active substances in pharmaceuticals. They are prepared by subjecting for example a compound of the formula <IMAGE> in which X1 is a nucleofugic leaving group, or a salt thereof, to intramolecular cyclisation.</p> |
