| 摘要 |
NEW MATERIAL:The compound of formula I (A is group of formula II, formula III, etc.; X is ethylene or cis-vinylene; Y is ethylene or trans-vinylene; R is H or 1-12C alkyl; R<1> is single bond or 1-5C alkylene; R<2> is 1-8C alkyl, 4-7C cycloalkyl, etc.; R<3>-R<5> are H or 1-4C alkyl; the wavy line represents that the configuration of the group attached thereto is alpha-, beta- or their mixture). EXAMPLE:15-O-(3,3-Dimethyl)acryloyl-PGD2 methyl ester. USE:An antitumor agent exhibiting excellent antitumor activity which is not found hitherto in the conventional prostaglandin-minic compounds. PREPARATION:The compound of formula I can be prepared by oxidizing the 9- hydroxyl group or 11-hydroxyl group of the compound of formula IV to oxo group.
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