| 摘要 |
NEW MATERIAL:The beta-lactam compound of formula I (X is CH2, S or O; Y is OH, acyloxy or amino; A is phenyl, naphthalene or heterocyclic group; R1 is H, OH, methoxy or alkyl; R2 is H, halogen, methoxy, etc.; R3 is H, alkali metal, etc.; R4 and R5 are H, alkyl, or together with bonded C atom form cycloalkylidene; l is 0-3; m is 0 or 1; n is 1-5). EXAMPLE:(6R,7S)-7-[2-( 2-Aminothiazol-4-yl )-2-syn-(3,4-diacetoxy-benzoyloxyimino) acetamido]-1-azabicyclo[4,2,0]oct-2-ene-8-oxo-2-carboxylic acid. USE:Bactericide and disinfectant for Gram-positive bacteria, Gram-negative bacteria, etc. PREPARATION:The objective compound of formula I can be prepared e.g. by condensing the novel carboxylic acid of formula II (Z is amino, etc.; Y<1> is Y, etc.) or its reactive derivative with the compound of formula III, and eliminating the protecting group from the resultant compound of formula IV. |
