| 摘要 |
PURPOSE:To obtain a solid drug having improved disintegrating property, by incorporating calcium cellulose glycolate having a specific particle size as a disintegrating agent together with another excipient in a main drug, and shaping the resulant mixture. CONSTITUTION:A solid drug having improved disintegrating property is obtained by using calcium cellulose glycolate having 0.30-0.80 carboxymethyl group substitution degree based on anhydroglucose units and such a particle size as to pass through a 145-mesh screen and not to pass through a 300-mesh screen as a disintegrating agent. At present, the calcium cellulose glycolate is used as the most improved disintegrating agent in the largest quantity, but only a single grade under the trademark of ''ECG-505''. This invention is based on findings that the above-mentioned calcium cellulose glycolate without fine powder fraction as described above has better disintegrating property than the commercially available product and characterized by using the above-mentioned calcium cellulose glycolate as the disintegrating agent.
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