| 摘要 |
PURPOSE:To produce the titled compound useful as a non-steroidal anti-inflammatory agent, in high yield with a simple operation, by reacting a specific non- toxic trivalent iodine compound with a specific carbonyl compound in the presence of an orthocarboxylic acid ester. CONSTITUTION:The objective compound of formula III (R'' is alkyl) is prepared economically by reacting the non-toxic trivalent iodine compound of formula I (Ar is aromatic hydrocarbon group; X and Y are group eliminable as anion) with a carbonyl compound of formula II (Ar' is aromatic hydrocarbon group; R and R' are H or alkyl) in the presence of an orthocarboxylic acid ester. The reaction proceeds smoothly and is completed in a short time by heating e.g. in the presence of concentrated sulfuric acid. Although the compound Ar-I is produced from the compound of formula I as a by-product, it can be recovered, converted to the compound of formula I and reused, and accordingly, the production cost of the objective compound can be reduced remarkably.
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