| 摘要 |
NEW MATERIAL:The compound of formula I [R1 is H or methoxy; R2 is univalent substituent group; m is 0-3; A is group of formula II or formula III (R3 and R4 are H or lower alkyl)] and its salt. EXAMPLE:7beta-[D-2-( 4-Carboxymethoxyphenyl )-2-( 6,7-dihydroxy-2-methyl-4-oxo- 4H-1-benzopyran-3-carboxamido )acetamido]-3-( 4-carbamoyl-pyridinium )methyl-3- cephem-4-carboxylate. USE:An antibacterial agent effective to Gram-negative bacteria, especially Pseudomonas aeruginosa, Klebsiella pneumoniae, Serratia marcescens, etc. It has high solubility in water, and is convenient to use as an injection. PREPARATION:The compound of formula IV (R5 is lower alkanoyl or benzoylthio) or its salt is made to react with the compound of formula V to obtain the objective compound.
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