| 摘要 |
Anilinoimidazolines(I; R1=substituted aryl; R2, R3=H, halogen, alkyl, alkoxy, alkanesulfonamido, haloalkyl, cabamoyl, NO2, amino, cyano, SO2NH2; A-O, CH2; n-1-2) used as antihypertensive, anti-inflammatory, analgesia, were prepd. by the reaction of III or its salt with ethylenediamine. In an example, 8.7g 1-[2-(3,5-dicholorophenoxy)Phenyl thiourea and 4.8g methyliodide in 100ml CH3OH was refluxed and stirred 1hr. A mixt. of the residue and 5.1g of ethylenediamine in 100cc methanol was refluxed and stirred 3hr. The product(X) was purified by recrystallization from ethylacetate gave 5.1g. (m.p 168-170≦̸C) |
