发明名称 14-ACYLOXY-2'-HALO-ANTHRACYCLINE ANTI-CANCER ANTIBIOTICS
摘要 Compounds of the formula (I) and pharmaceutical preparations containing the same are disclosed <CHEM> wherein R<1> is -OOCR<3> or -OOC(CH2)nCOOR<4>; R<2> is hydrogen, hydroxy or methoxy; one of X and X min is a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine and the other is hydrogen; one of Y and Y min is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; one of Z and Z min is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; R<3> is an alkyl group containing 1 to 8 carbon atoms; R<4> is a hydrogen atom, a metal atom, or an alkyl group containing 1 to 4 carbon atoms; and n is an integer of 0 to 6. These compounds are effective in treating a broad spectrum of neoplastic conditions including leukemias, lymphomas, and various tumors.
申请公布号 ZA8309396(B) 申请公布日期 1984.08.29
申请号 ZA19830009396 申请日期 1983.12.19
申请人 UNIV OHIO STATE RES FOUND 发明人 HORTON DEREK;PRIEBE WALDEMAR;WOLGEMUTH RICHARD L
分类号 C07H15/252 主分类号 C07H15/252
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