发明名称 14-Acyloxy-2'-halo-anthracycline anti-cancer antibiotics.
摘要 <p>Compounds of the formula (I) and pharmaceutical preparations containing the same are disclosed &lt;CHEM&gt; wherein R&lt;1&gt; is -OOCR&lt;3&gt; or -OOC(CH2)nCOOR&lt;4&gt;; R&lt;2&gt; is hydrogen, hydroxy or methoxy; one of X and X min is a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine and the other is hydrogen; one of Y and Y min is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; one of Z and Z min is hydrogen and the other is selected from the group consisting of hydrogen, hydroxy and acyloxy; R&lt;3&gt; is an alkyl group containing 1 to 8 carbon atoms; R&lt;4&gt; is a hydrogen atom, a metal atom, or an alkyl group containing 1 to 4 carbon atoms; and n is an integer of 0 to 6. These compounds are effective in treating a broad spectrum of neoplastic conditions including leukemias, lymphomas, and various tumors.</p>
申请公布号 EP0116222(A1) 申请公布日期 1984.08.22
申请号 EP19830307715 申请日期 1983.12.19
申请人 THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION 发明人 PRIEBE, WALDEMAR;HORTON, DEREK;WOLGEMUTH, RICHARD L.
分类号 C07H15/252;(IPC1-7):07H15/24;61K31/00 主分类号 C07H15/252
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