| 摘要 |
<p>Renin-inhibiting tetra-, penta- or hexapeptide analogues of formula (I), where X and W are terminal groups; D, E, B, and Z (of which any one or except with "reduced" analogues any two may be absent) are aromatic, lipophilic or (in the case of E) aromatic lipophilic or basic amino acid or amino acid analogue residues; and A is an analogue of a lipophilic or aromatic dipeptide residue wherein the peptide link is replaced by a one- to four-atom carbon or carbon-nitrogen link which as such or in hydrated form is an unhydrolysable tetrahedral analogue of the transition state, formula (II), of the peptide bond. </p> |
