| 摘要 |
PURPOSE:To obtain a lignan useful as an antitumor agent or microtube polymerization inhibitor, etc. in high yield in one stage, by oxidizing a phenylpropene with an oxidizing composition prepared by dissolving chromic acid anhydride in a strong acid and an organic solvent in the above-mentioned organic solvent. CONSTITUTION:A compound of formula I (R1-R5 are H or electron donative group, such as halogen, lower alkoxyl, benzyloxy, NH2, etc.; two thereof together form methylenedioxy or ethylenedioxy group; at least one of the o-positions with respect to the side chain on the benzene ring is H) is oxidized with an oxidizing composition prepared by dissolving chromic acid anhydride in a strong acid and one or more organic solvents selected from acetonitrile, propionitrile, butyronitrile and nitromethane in the above-mentioned organic solvents to give the aimed compound of formula II (R7 is H or OH) useful as the above-mentioned medicine, e.g. podophyllotoxin, etc. advantageously by easy operation. |
