| 摘要 |
<p>2-Methyl-3-R4-CO-4-R3-5 -(4,5-dihydro-4R-4-R1-2-oxazolyl)-5-R2-1,4-di hydro-pyridine derivs. and related cpds. of formula (I) and their acid addn. salts, as the separate isomers or their mixts. are new. - (where R, R1, independently are 1-4C alkyl or alkoxy-alkyl; R2 is alkyl, phenyl or thienyl; R3 is 5-7C cycloalkyl, 7-9C bicycloalkenyl, heteroaryl, (esp. furanyl, indolyl, pyridyl or thienyl) or aryl (esp. naphthyl or phenyl (opt. substd. by acetamino, 1-4C alkyl, 1-4C alkoxy, cyano, halo, hydroxy, nitro, trifluoromethyl, trifluoromethylsulphonyl or methylsulphonyl)); R4 is alkyl, alkoxyalkyl, aminoalkyl, haloalkyl or dialkylamino alkyl; R5 is alkyl or aryl; m is 0 or 1 and n is 0, 1 or 2. Alkyl and alkoxy gps. where not defined are 'lower' gps. - Calcium antagonists useful for treatment of cardiovascular disorders esp. as vasodilators for treatment of angina pectoris and hypertension and prevention of ischemic attacks. (I) are administered orally or parenterally in doses of 5-500 mg. (0/0) GBAB- GB2139212 B A compound having the formula (I) and the acid addition salts thereof wherein R and R1 are independently selected from hydrogen, lower (C1-C4) alkyl or lower alkoxy-lower alkyl groups; R2 is lower alkyl, phenyl, or thienyl; R3 is cycloalkyl or 5 to 7 carbon atoms, bicycloakenyl or 7 to 9 carbon atoms, hetaryl, aryl; R4 is lower alkyl, lower alkoxy-lower alkyl, amino-lower alkyl, halo-lower alkyl, or di-lower alkyamino-lower alkyl; R5 is lower alkyl or aryl; m is 0 or 1; and n is 0, 1 or 2.o - GB2185978 B Compounds of formula (II) wherein R and R1 are independently selected from hydrogen, lower (C1-C4) alkyl or lower alkoxy-lower alkyl groups; R2 is lower alkyl, phenyl or thienyl; R5 is lower alkyl or aryl; m is 0 or 1; and n is 0, 1 or 2.</p> |
