| 摘要 |
1,127,750. Steroids. ROUSSEL UCLAF. 30 Dec., 1965 [31 Dec., 1964; 26 Feb., 1965; 24 March, 1965; 14 June, 1965; 3 Sept., 1965; 17 Sept., 1965], No. 7661/68. Divided out of 1,127,746. Heading C2U. The invention comprises 3,3-dialkoxy-17α- alkynyl - 17# - hydroxy - estra - 5(10),9(11) - dienes and their preparation by reacting the corresponding 17-keto compound with an alkynyl magnesium halide, 17α - alkynyl - 17# - hydroxy - estra - 5(10),9(11) - diene - 3 - ones and their preparation by hydrolysing the corresponding 3,3-dialkoxy compounds, 3,3-dialkoxy- 13# - alkyl - 17# - hydroxy - gona - 5(10),9(11) and their preparation from the corresponding 3-ones with an alkanol in the presence of acetyl chloride, 3,3 - dialkoxy - 13# - alkyl - gona - 5(10),9(11) - 17 - ones and their preparation by oxidizing the corresponding 17-ones, 3-enamino- 17α - alkynyl - 17# - hydroxy - 13# - alkyl - gona - 3,5(10),9(11)-trienes and their preparation by reacting a 17α - alkynyl - 17# - hydroxy - 13# - alkyl - gona - 4,9 - diene - 3 - one with an amine, 3 - alkylenedioxy - 17α - alkyl - 17# - hydroxy - 13# - alkyl - gona - 5(10),9(11) - dienes and their preparation by reacting the corresponding 17-ones with alkyl lithium, 17α-alkyl- 17# - hydroxy - 13# - alkyl - gona - 5(10),9(11) - diene-3-ones and their preparation by hydrolysing the corresponding 3-alkylenedioxy compounds, 3,3 - dialkoxy - 17# - hydroxy - 17α - alkyl - estra - 5(10),9(11) - dienes and their preparation by reacting the corresponding 17- ones with alkyl lithium, 3,3-dialkoxy-17#- hydroxy - 17α - alkenyl - estr - 5(10),9(11) - dienes and their preparation by reacting the corresponding 17-ones with an alkenyl magnesium halide, 17#-hydroxy-17α-alkenyl-estra- 5(10), 9(11)-diene-3-ones and their preparation by hydrolysing the corresponding 3,3-dialkoxy compounds, 3 - enamino - 17α - alkyl - 19 - nor - pregna - 3,5(10),9(11) - triene - 20 - ones and their preparation by reacting a 17α-alkyl-19- nor-pregna-4,9-diene-3,20-dione with an amine, 17α - alkyl - 19 - -nor -pregna-5(10),9(11) - diene- 3,20-diones and their preparation by hydrolysing the corresponding 3-enamines, 3,3-dialkoxy- 7α,17α - dialkyl - 17# - hydroxy - estr - 5(10),- 9(11)-dienes by reacting the corresponding 17- ones with an alkyl magnesium halide, and 7α,17α - dialkyl - 17# - hydroxy - estra - 5(10), 9(11)-diene-3-ones and their preparation by hydrolysing the corresponding 3,3-dialkoxy compounds. |
