| 摘要 |
Cephalosporin antibiotics of general formula <IMAGE> (wherein Y represents a carbon- linked 5- or 6-membered unsaturated heterocyclic ring containing at least one nitrogen atom, such as pyridine or tetrazole, which ring may also contain one or more sulphur atoms and/or may be substituted by one or more C1-4 alkyl, oxo, hydroxy or carbamoyl-methyl groups such as dioxotriazine), and non-toxic salts and non-toxic metabolically labile esters thereof and pharmaceutical compositions containing them are described. The compounds exhibit broad spectrum antibiotic activity both in vitro and in vivo, having good activity against both Gram-positive and Gram-negative organisms. |
