| 摘要 |
<p>The title compds. (I; R15=F, Cl, Br, iodo, C1-4 alkoxy, C1-4 alkylthio; R13=H, ester; n=o 1, 2) were prepd. asβ-lactamase inhibitors forβ-lactam antibiotic formulations. Thus, 2.95g Na 6-chloro-6-iodopenicillanic acid was dissolved in 125mL benzene and treated with 1.08mL Et3N. This mixt. was reacted with 0.977mL trimethylcillyl chloride and refluxed with 15mg azobisisobutyronitrile and 2.02mL tri-n-butylene-HCl to give Na 6-β-chloropenicillanic acid.</p> |
