| 摘要 |
The present invention provides compounds of formula (2):- …<CHEM>… and their pharmaceutically acceptable salts which are useful as histamine H1-antagonists. In formula (2)… R<1> is halogen, nitro, amino (or a pharmaceutically acceptable derivative of the amino group which is convertible in vivo into amino) or C1-4 alkyl;… R<2> is halogen, nitro, amino (or a pharmaceutically acceptable derivative of the amino group which is convertible in vivo into amino), C1-4 alkyl or C3-4 alkoxy;… R<3> is a C1-4 alkylene group; and… R<4> is phenyl optionally bearing one or two substituents which are the same or different and are halogen, hydroxy, C1-4 alkyl or C1-4 alkoxy or a methylene-dioxy group. |
