7-ACYLTHIO-15,16-METHYLENE-3-OXO-17-PREGNA-1,4-DIENE 21,17-CARBOLACTONES,THEIR PREPARATION AND USE AS MEDICINAL AGENTS

摘要

7 alpha -acylthio-15,16-methylene-3-oxo-17 alpha -pregna-1,4-diene-21,17-carbolactones of the formula wherein the 15,16-methylene group can be in the alpha - or beta - configuration, and R is a lower alkyl residue, have altialdosterone activity. They are prepared from corresponding DELTA <4>-unsaturated compounds by chemical or microbiological 1,2-dehydrogenation.