Neue 2,6-Bis(dialkanolamino)-pyrimido-[5,4-d]pyrimidine und Verfahren zu ihrer Herstellung

摘要

1313056 Pyrimidopyrimidines DR KARL THOMAE GmbH 19 April 1971 [30 Jan 1970] 20660/71 Heading C2C Compounds of the general formula (R 1 , 2 =C 1-3 alkyl, or NR 1 R 2 =1,2,5,6-tetrahydropyridino or hexamethyleneimino, or piperidino optionally substituted by 1 or 2 Me or Et; R 3 , 4 = dialkanolamino in which the hydroxyalkyl radicals each contain 2-6 C, provided that when R 3 = R 4 the group contains a C 4-6 hydroxyalkyl radical) are prepared by (a) reducing a compound of the formula and oxidizing the product, optionally followed by isomer separation, or (b) reacting a compound of the formula (A=radical which may be interchanged with NR 1 R 2 , A 1 =R 3 , A 2 =R 4 ; A=NR 1 R 2 , A 1 =R 3 , A 2 = radical which may be interchanged with R 4 ; A=NR 1 R 2 , A 2 =R 4 , A 1 =radical which may be interchanged with R 3 ; or A=NR 1 R 2 , A 1 , 2 =radicals which may be interchanged with R 3 (=R 4 )) with R 1 R 2 NH, R 3 H or R 4 H. The above compounds possess heart and circulation activity and inhibit thrombocyte aggregation. They may be administered in the form of pharmaceutical preparations containing them in association with a carrier.