PROCESS FOR PREPARING NOVEL GLYCEROL DERIVATIVES HAVING PHARMACOLOGICAL ACTIVITY AND THE DERIVATIVES SO OBTAINED

摘要

A process for preparing a mixture of glyceryl 1,3-bis-(di-n-propylacetate) and 1,2-bis-(di-n-propylacetate) in a ratio of about 1.43 to about 1,54, whereby one equivalent of 1.3-dichloro-2-propanol is esterified at a temperature between 100 and 110.degree.C and for 5 to 10 hours with two equivalents of an alkali metal salt of di-n-propylacetic acid in N,N-dimethylformamide as solvent followed by rectification of the mixture of esters so obtained. The esters according to the invention and mixtures thereof are endowed with biochemical and pharmacological properties likeby to render them particularly useful in the treatment of pathological conditions due to disturbances of the central nervous systems and disorders relating to the field neutropsychiatry.