发明名称 |
VERFAHREN ZUR HERSTELLUNG VON 1-ISOPROPYLAMINO-3(4-(2-METHOXY[THYL)-PHENOXY)-2-PROPANOL. |
摘要 |
A process for the preparation of the therapeutically active 1-isopropylamino-3-[4-(2-methoxyethyl)phenoxy]-2-propanol of the formula <CHEM> comprising the reaction of 1,2-epoxy-3-[4-(1-acetoxy-2-methoxy-ethyl)phenoxy]-propane with isopropylamine yielding 1-isopropylamino-3-[4- (1-acetoxy-2-methoxyethyl)phenoxy]-2-propanol, which is reduced either by catalytic hydrogenolysis or with sodium borohydride in an inert solvent containing trifluoroacetic acid or methanesulfonic acid to a compound of formula (I). |
申请公布号 |
AT6501(T) |
申请公布日期 |
1984.03.15 |
申请号 |
AT19810200616T |
申请日期 |
1981.06.03 |
申请人 |
AKTIEBOLAGET HAESSLE |
发明人 |
KOSKENNISKA, LASSE ANTERO;ELORANTA, MAIRE MARJATTA |
分类号 |
C07C213/04;A61K31/135;C07C;C07C217/32 |
主分类号 |
C07C213/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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