| 摘要 |
NEW MATERIAL:The compound of formula I [R is (substituted) phenyl; A is lower alkylene] or its salt. EXAMPLE:19-Deformyl-23-demycinosyl-23-O-benzyldesmycosin. USE:Antibacterial agent effective to Gram-positive bacteria, Gram-negative bacteria, etc. Remedy for infectious diseases of animals, and feed additive. PROCESS:The compound of formula II (R1 is OH-protecting group) (e.g. 2',4'- di-O-acetyl-19-deformyl-23-demycinosyldesmycosin, etc.) is alkylated at the 23-O with the alkylation agent of formula R-A-X (X is halogen) in the presence of a base, and the protective groups of the 2'- and 4'-hydroxyl groups are removed. |
