摘要 |
A large no. of cephalosporins syn-I[R1=II; R7=(protected) amino, OH, lower alkyl; R2=optionally substituted aliph.; R3=(protected) carboxy; R4=carbamoyloxymethyl, OHMe, formyl, heterocyclicthiomethyl were prepd. Thus, a mixt. contg. 1.2g bis(trimethylcythyl) ! acetamid and 0.53g 7-amino-3-(1-methyl-lH-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxyla- ! te in 7mL Et. acetate were reacted with 1.5mL ethylacetate soln. contg. 0.3g syn-2-methoxyimino-2-(-2-methyl-1,3-thiazol-4-yl)acetate, 0.26g phosphorousoxychloride, and 0.15g dimethyl formamide to give 0.28g syn-7-[2-methoxyimino-2-(2-methyl-1,3-thiazol ! -4-yl)acetamido -3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate.
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